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The agonist NLY01 exemplifies this mechanism by crossing the blood-brain barrier to directly target microglial GLP-1Rs, in addition to blocking dopaminergic neuron loss in Parkinson's models through preventing microglia activation and generation of neurotoxic reactive astrocytes [47] and potentially PI3K/AKT-mediated survival pathways [24] (Fig

Otherwise, they may recommend focusing on portion control, cutting out sugary and highly processed foods, and eating more vegetables, lean proteins, and healthy fats

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exenatide once weekly, dulaglutide, albiglutide, liraglutide [12]